Single screw extruder performance characteristics during processing of corn protein blends

During the last decade, the global biofuels industry has experienced exponential growth. By-products such as distillers dried grains with solubles (DDGS) have grown in parallel. DDGS is primarily an animal feed, but it has also been shown to be suitable as a biopolymer. In this study, the extrusion processing behaviour of DDGS was evaluated. Prior to processing, water was added to DDGS at a level of 3 kg DDGS to 1.5 kg water (water at 50 parts per hundred (pph)). Additionally, a DDGS/water blend with 50 pph CaCO₃ was used as a tracer to determine residence time during processing. The blends were processed in a single screw autogenous extruder, which relied solely upon friction for dissipative heating. Two die plates were used: one consisted of 6 orifices equally spaced, 2 mm diameter each, with a total opening area of 18.85 mm²; the other consisted of multiple orifices (960 in total) arranged concentrically around the plate, with a diameter of 2.30 mm each, for a total opening area of 3988.45 mm². Processing began with DDGS blends without tracer; after reaching steady state, the tracer blend was introduced. Samples were collected every 5 sec during processing to determine extrudate changes over time. Extruder power consumption, mass flow rate, and temperature profile were determined during processing. Extrudates were analysed for Hunter colour (L-a-b) changes over time. Extrusion processing characteristics were highly influenced by the die opening area. Die exit temperatures ranged from room temperature (25°C) to more than 100°C, purely due to increased friction for the smaller die opening. Future work should characterize the mechanical properties of these extrudates to assess their suitability as either bioplastic feedstocks or pelletized animal feeds

Processibility of corn protein blends and resulting properties of the extrudates

During the last decade, the global biofuels industry has experienced exponential growth. By-products such as high protein corn gluten meal (CGM) and high fibre distillers dried grains with solubles (DDGS) have grown in parallel. CGM has been shown to be suitable as a biopolymer; the high fibre content of DDGS reduces its effectiveness, although it is considerably cheaper. In this study, the processing behaviour of CGM and DDGS blends were evaluated and resulting extrudate properties were determined. Prior to processing, urea was used as a denaturant. DDGS:CGM ratios of 0, 33, 50, 66 and 100% were processed in a single screw extruder, which solely used dissipative heating, with a 2 mm circular die. Resulting screw speeds ranged from 216 to 228 rpm, and die exit temperatures ranged from 96 to 150oC. Blends containing DDGS were less uniformly consolidated and resulted in more dissipative heating. Blends showed multiple glass transitions, which is characteristic of mechanically compatible blends. Transmission electron microscopy revealed phase separation on a micro-scale, although distinct CGM or DDGS phases could not be identified. On a macro-scale, optical microscopy suggested that CGM-rich blends were better consolidated, supported by visual observations of a more continuous extrudate formed during extrusion. As with all biological materials, the extruded blends exhibited sorption behaviour over time, the magnitude of which varied according to blend ratio. EMC values ranged from approximately 0% to nearly 50%, depending upon the humidity level and blend ratio. Nonlinear regression was successfully used to model the effects of relative humidity and blend ratio on the equilibrium moisture contents, with a coefficient of determination of 99%. Future work should aim to also characterize the mechanical properties of these blends to assess their suitability as either bioplastic feedstock or pelletized livestock feed

Patent related indicators for assessing knowledge-generating institutions: towards a contextualised approach.

This contribution aims at examining the extent to which patent related indicators are relevant for shedding light on the notion of excellence within knowledge generating institutions. Traditionally, excellence has been looked upon as the ability to create interesting and valuable new scientific concepts, theories and data. From such a perspective, scientific excellence can be assessed through scientometric measures of publication output and impact. The recent interest in the 'entrepreneurial' phenomenon within knowledge generating institutes justifies efforts to examine the relevancy of broadening the set of indicators used to assess such institutions into the direction of entrepreneurial excellence. In this paper we will examine the relevancy of using patent data in order to delineate such additional, more entrepreneurial oriented, indicators. The arguments and findings presented in this respect will lead us to a plea for the use of these indicators in a contextualized manner.Science; Effectiveness; Patents; Country; Performance; Variance analysis;

Do science-technology interactions pay off when developing technology? An exploratory investigation of 10 science-intensive technology domains.

In this paper we investigate the impact of science – technology (S&T) interactions on the effectiveness of technology development. The number of references in patents to scientific articles is considered as an approximation of the intensity of S&T interaction whereas a country's technological performance is measured both in terms of its technological productivity (i.e. number of patents per capita), and its relative technological specialization (i.e. RTA-index). We use USPTO patent-data for eight European countries in ten technological domains. A variance analysis (ANOVA) is applied. Country as an independent variable does not explain a significant portion of the observed variance in science interaction intensity (p=0.25). Technology domain, however, explains a significant portion of the observed variance (pScience; Effectiveness; Patents; Country; Performance; Variance analysis;

Interventions to facilitate return to work in adults with adjustment disorders

BACKGROUND: Adjustment disorders are a frequent cause of sick leave and various interventions have been developed to expedite the return to work (RTW) of individuals on sick leave due to adjustment disorders. OBJECTIVES: To assess the effects of interventions facilitating RTW for workers with acute or chronic adjustment disorders. SEARCH METHODS: We searched the Cochrane Depression, Anxiety and Neurosis Review Group's Specialised Register (CCDANCTR) to October 2011; the Cochrane Central Register of Controlled Trials (CENTRAL) to Issue 4, 2011; MEDLINE, EMBASE, PsycINFO and ISI Web of Science, all years to February 2011; the WHO trials portal (ICTRP) and ClinicalTrials.gov in March 2011. We also screened reference lists of included studies and relevant reviews. SELECTION CRITERIA: We selected randomised controlled trials (RCTs) evaluating the effectiveness of interventions to facilitate RTW of workers with adjustment disorders compared to no or other treatment. Eligible interventions were pharmacological interventions, psychological interventions (such as cognitive behavioural therapy (CBT) and problem solving therapy), relaxation techniques, exercise programmes, employee assistance programmes or combinations of these interventions. The primary outcomes were time to partial and time to full RTW, and secondary outcomes were severity of symptoms of adjustment disorder, work functioning, generic functional status (i.e. the overall functional capabilities of an individual, such as physical functioning, social function, general mental health) and quality of life. DATA COLLECTION AND ANALYSIS: Two authors independently selected studies, assessed risk of bias and extracted data. We pooled studies that we deemed sufficiently clinically homogeneous in different comparison groups, and assessed the overall quality of the evidence using the GRADE approach. MAIN RESULTS: We included nine studies reporting on 10 psychological interventions and one combined intervention. The studies included 1546 participants. No RCTs were found of pharmacological interventions, exercise programmes or employee assistance programmes. We assessed seven studies as having low risk of bias and the studies that were pooled together were comparable. For those who received no treatment, compared with CBT, the assumed time to partial and full RTW was 88 and 252 days respectively. Based on two studies with a total of 159 participants, moderate-quality evidence showed that CBT had similar results for time (measured in days) until partial RTW compared to no treatment at one-year follow-up (mean difference (MD) -8.78, 95% confidence interval (CI) -23.26 to 5.71). We found low-quality evidence of similar results for CBT and no treatment on the reduction of days until full RTW at one-year follow-up (MD -35.73, 95% CI -113.15 to 41.69) (one study with 105 participants included in the analysis). Based on moderate-quality evidence, problem solving therapy (PST) significantly reduced time until partial RTW at one-year follow-up compared to non-guideline based care (MD -17.00, 95% CI -26.48 to -7.52) (one study with 192 participants clustered among 33 treatment providers included in the analysis), but we found moderate-quality evidence of no significant effect on reducing days until full RTW at one-year follow-up (MD -17.73, 95% CI -37.35 to 1.90) (two studies with 342 participants included in the analysis). AUTHORS' CONCLUSIONS: We found moderate-quality evidence that CBT did not significantly reduce time until partial RTW and low-quality evidence that it did not significantly reduce time to full RTW compared with no treatment. Moderate-quality evidence showed that PST significantly enhanced partial RTW at one-year follow-up compared to non-guideline based care but did not significantly enhance time to full RTW at one-year follow-up. An important limitation was the small number of studies included in the meta-analyses and the small number of participants, which lowered the power of the analyses

Sequence analysis and genomic organization of Aphid lethal paralysis virus: a new member of the family Dicistroviridae

The complete nucleotide sequence of the genomic RNA of an aphid-infecting virus, Aphid lethal paralysis virus (ALPV), has been determined. The genome is 9812 nt in length and contains two long open reading frames (ORFs), which are separated by an intergenic region of 163 nt. The first ORF (5' ORF) is preceded by an untranslated leader sequence of 506 nt, while an untranslated region of 571 nt follows the second ORF (3' ORF). The deduced amino acid sequences of the 5' ORF and 3' ORF products respectively showed similarity to the non-structural and structural proteins of members of the newly recognized genus Cripavirus (family Dicistroviridae). On the basis of the observed sequence similarities and identical genome organization, it is proposed that ALPV belongs to this genus. Phylogenetic analysis showed that ALPV is most closely related to Rhopalosiphum padi virus, and groups in a cluster with Drosophila C virus and Cricket paralysis virus, while the other members of this genus are more distantly related. Infectivity experiments showed that ALPV can not only infect aphid species but is also able to infect the whitefly Trialeurodes vaporariorum, extending its host range to another family of the order Hemipter

Non-alcoholic fatty liver disease: Current therapeutic options

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and has an estimated global prevalence of 25%. NAFLD is found in up to 80% of people with obesity and over 60% of patients with diabetes. Cardiovascular disease is the main cause of mortality, followed by extra-hepatic cancers and then liver-specific complications of cirrhosis and hepatocellular carcinoma. Lifestyle modification remains the primary intervention in NAFLD. Weight loss achieved through dietary modification and exercise can lead to histologic improvement and reversal of metabolic complications. Current drug therapy is limited to pioglitazone and vitamin E; however, several agents are currently under phase III development. This review summarises the current treatment options in NAFLD